王志云

姓名：王志云

职称：副教授，硕士生导师

系别：环境科学与工程学院  环境科学系

专业：环境与生态

主要研究方向：环境病毒学、环境微塑料与微生物风险

办公电话：022-87402272

电子邮箱：zhiyun_wang@tju.edu.cn

教育经历：

本科：1990.9-1994.7   西北大学 生物系

硕士：1996.9-1999.7   西安交通大学医学院 病原生物学

博士：1999.9-2002.7   中国医学科学院 北京协和医科大学 病原生物学

博士后：2003.9-2009.9 美国约翰斯•霍普金斯大学 生物医学工程系

工作经历：

1994.7-1996.9 西安医科大学 基础医学部  助教

2002.7-2003.9  西安交通大学医学院 讲师

2010.9-2013.12 中国科学院微生物研究所  副研究员

2014.1-至今  天津大学环境科学与工程学院  副教授

获奖情况：2025年天津市科学技术进步奖二等奖

学术兼职：天津市预防医学会卫生检验分会委员

主讲课程：《环境生物化学》《环境与传染病》《环境毒理学》 

研究领域和兴趣：

1.环境中新发病原微生物：研究宿主-病原微生物相互作用机制，预防病原微生物传播并寻找新靶点开发潜在药物。

2.环境微塑料与微生物风险：揭示微塑料促进耐药性/致病菌的毒力表达的分子机制。

主持的代表性科研项目：

1.科技部国家重点研发计划 课题/子课题 重要公共场所生物恐怖防控技术研究/重要公共场所生物恐怖威胁因子现场防控新技术和新设备 课题编号：2021YFC2600503

2.科技部国家重点研发计划 纳米科技专项 课题/子课题“基于稀土发光纳米技术的病原体检测研究” 课题编号：2017YFA0205102

3.国家自然科学基金面上项目 人肠道病毒D68型(EV-D68)调节“脂代谢-铁死亡”串扰cGAS-STING通路实现免疫逃逸的机制研究 项目编号：32570184

4.国家重点基础研究发展计划 课题/子课题： 重要病毒跨种间感染与传播致病的分子机制研究/重要病毒分子变异、进化规律及其生物学特性 课题编号：2011CB504702

5.国家重点基础研究发展计划 课题/子课题：病毒潜伏感染的分子机制/病毒潜伏感染与激活的信号转导调控课题编号：2011CB504802

代表性论文：

1.Li X, Pang Y, Liu Z, Mu J, Wang S, Chen Z, Wang Z*, Wang T*. Two-component system HprS/HprR enhances kidney colonization of uropathogenic Escherichia coli CFT073 by increasing flagellar expression.Cell Rep. 2026 Feb 24;45(2):116932. doi: 10.1016/j.celrep.2026.116932. Epub 2026 Jan 31.(通讯作者，中科院一区期刊)

2.Wang Z#,Chen Z，Wang S，Cui L,Tang M ,Liu X*,Wang T *,Li X*.PVC microplastics facilitate uropathogenic Escherichia coli pathogenicity by enhancing host cell invasion and mitochondrial-dependent pyroptosis.Nature communication .2026 June16.doi:10.1038/s41467-026-74453-7.(并列第一作者，中科院一区期刊)

3.Liu Z, Huang M, Liu Y, Cui L, Shi X, Chen H, Gao X, Wang Z, Lin Q, Wang Z*, Teng Y*, Wang T*.RG7388 inhibits SFTSV replication by suppressing MDM2-mediated p53 degradation and preventing apoptosome disruption.Sci Bull (Beijing). 2026 Jan 15;71(1):55-59. doi: 10.1016/j.scib.2025.06.028. Epub 2025 Jun 21.(通讯作者，中科院一区期刊)

4.Wang Y, Li J, Wang Z*, Liu X*.Micro-nanoplastics enhance viral survival and infectivity: Experimental evidence from a bacteriophage D1 model system..Environ Pollut. 2026 Feb 1;390:127468. doi: 10.1016/j.envpol.2025.127468. Epub 2025 Nov 29.(通讯作者)

5.Tan R, Zhang Y, Huang M, Chen H, Liu Z, Wang Z, Li X, Wang T*, Wang Z*.EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA.PLoS Pathog. 2025 Apr 28;21(4):e1013098. doi: 10.1371/journal.ppat.1013098. eCollection 2025 Apr.(通讯作者，中科院1区期刊)

6.The structural protein VP3 of enterovirus D68 interacts with MAVS to inhibit the NF-κB signaling pathway.Chen H, Huang M, Hou B, Liu Z, Tan R, Cui L, Wang T*, Wang Z*.J Virol. 2025 Apr 15;99(4):e0016325. doi: 10.1128/jvi.00163-25. Epub 2025 Mar 5.(通讯作者)

7.Cui J, Dai Y, Xu S, Zhang P, Wang Z*, Liu X*.Ultralight Carbon Aerogels with Highly Hierarchical Porous Structures Synthesized from Sodium Alginate-Nanocellulose Composites for High-Performance Supercapacitors.Polymers (Basel). 2025 Jun 1;17(11):1544. doi: 10.3390/polym17111544.(通讯作者)

8.Li H, Chen H, Wang J, Li J, Liu S, Tu J, Chen Y, Zong Y, Zhang P, Wang Z*, Liu X*. Influence of Microplastics on the Growth and the Intestinal Microbiota Composition of Brine Shrimp.Front Microbiol. 2021 Sep 29;12:717272. doi: 10.3389/fmicb.2021.717272. eCollection 2021.(通讯作者)

9.Zhang X, Zhang Y, Yang X, Wang Z*, Liu X*.Biochemical Oxygen Demand Prediction Based on Three-Dimensional Fluorescence Spectroscopy and Machine Learning.Sensors (Basel). 2025 Jan 24;25(3):711. doi: 10.3390/s25030711.(通讯作者)

10.Yuling Zhang#, Leling Xu#, Leling; Zhe Zhang, Xin Su, Zhiyun Wang*, Tao Wang*. Enterovirus D68 infection upregulates SOCS3 expression to inhibit JAK-STAT3 signaling and antagonize the innate interferon response of the host. Virologic Sinica. 2023, 38(5):755-766. (通讯作者)

11.Sihua Liu, Yazhi Su, Zhuozhuang Lu, Xiao-Hui Zou, Leling Xu, Yue Teng*, Zhiyun Wang*, and Tao Wang*. The SFTSV nonstructural proteins induce autophagy to promote viral replication via interaction with Vimentin. Journal of Virology. 2023, 97(4):e0030223.(通讯作者)

12.Jun Kang#, Mengqian Huang#, Jinyu Li#, Keke Zhang, Cheng Zhu, Sihua Liu, Zhenwei Zhou, Tao Wang*, Zhiyun Wang*. Enterovirus D68 VP3 targets the interferon regulatory factor 7 to inhibit1 type I interferon response. Microbiology Spectrum. 2023, e0413822. (通讯作者)

13.Jun Kang#; Zheng Pang#; Zhenwei Zhou; Xianhuang Li; Sihua Liu; Jinyan Cheng; Peiyuan Liu; Wenjie Tan; Zhiyun Wang*; Tao Wang*. Enterovirus D68 Protease 2Apro Targets TRAF3 To Subvert Host Innate Immune Responses, Journal of Virology, 2021, 95(3).(通讯作者)

14. Jinyan Cheng; Shuai Gao; Cheng Zhu; Sihua Liu; Jinyu Li; Jun Kang; Zhiyun Wang*; Tao Wang*. Typical Stress Granule Proteins Interact with the 3 ' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication , Journal of Virology, 2020, 94(7): e02041-19. (通讯作者)

15.Yexin Dai; Jie Ding; Jingyu Li; Yang Li; Yanping Zong; Pingping Zhang; Zhiyun Wang*; Xianhua Liu*. N, S and Transition-Metal Co-Doped Graphene Nanocomposites as High-Performance Catalyst for Glucose Oxidation in a Direct Glucose Alkaline Fuel Cell. Nanomaterials 2021, 11, 202.(通讯作者)

16.Jiao Wang; Xiaohui Zhang; Yang Li; Peng Liu; Xiaochen Chen; Pingping Zhang; Zhiyun Wang*; Xianhua Liu*. Sweet Drinks as Fuels for an Alkaline Fuel Cell with Nonprecious Catalysts. Energies 2021, 14, 206 (通讯作者)

17.Sihua Liu; Hongyun Liu; Jun kang; Leling Xu; Keke Zhang; Xueping Li; Wen Hou; Zhiyun Wang*; Tao Wang*. The Severe Fever with Thrombocytopenia Syndrome Virus NSs Protein Interacts with CDK1 To Induce G(2) Cell Cycle Arrest and Positively Regulate Viral Replication , Journal of Virology, 2020, 94(6): e01575-19.(通讯作者)

18.Sihua Liu; Hongyun Liu; Keke Zhang; Xueping Li; Yuqin Duan; Zhiyun Wang*; Tao Wang*. Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus,

Virol Sin. 2019 Oct;34(5):572-582. (通讯作者)

19.Yuqin Duan; Wei Wu; Qiuzi Zhao; Sihua Liu; Hongyun Liu; Mengqian Huang; Tao Wang; Mifang Liang*; Zhiyun Wang*. Enzyme-Antibody-Modified Gold Nanoparticle Probes for the Ultrasensitive Detection of Nucleocapsid Protein in SFTSV, International Journal of Environmental Research and Public Health, 2020, 17(4427). (通讯作者)

20.Minglei Pan; Shuai Gao; Zhenwei Zhou; Keke Zhang; Sihua Liu; Zhiyun Wang*; Tao Wang *. A reverse genetics system for enterovirus D68 using human RNA polymeraseI,Virus Genes, 2018, 54(4): 484-492(通讯作者)

21.Yuanli Mao; Enbo Cui; Chunmei Bao; Zhenhong Liu; Suming Chen; Juling Zhang; Huan Wang; Chenglong Zhang; Jing Zou; John D Klena; Baoli Zhu; Fen Qu*; Zhiyun Wang*. Changing Trends in Shigella Species and Serotype Distribution in a Beijing Referral Hospital from 1994 to 2010. Gut Pathog. 2013 Aug 7;5:21(通讯作者)

22.Zhiyun Wang, Jian Du, Pao-Lin Che, M Adam Meledeo, Kevin J Yarema. Hexosamine analogs: from metabolic glycoengineering to drug discovery, Curr Opin Chem Biol . 2009 Dec;13(5-6):565-72