崔洪洋

姓名：崔洪洋

职称：副研究员

系别：环境科学与生态系

主要研究方向：

1、环境暴露：暴露组学、新污染物检测技术、生物代谢小分子的鉴定和组学分析；

2、环境毒理：关键代谢靶点分析、致癌机制解析、蛋白质组学分析、蛋白质修饰及功能解析；

3、污染物治理：废水废固中污染物检测及无害化处理

办公电话：

电子邮箱：hongyang_cui@tju.edu.cn

通讯地址：天津市津南区雅观路135号天津大学，邮编300072

教育及工作经历：

2024.04-今：天津大学，环境科学与工程学院，副研究员

2021.07-2024.03：北京大学，城市与环境学院，博雅博士后，合作导师 王志恒教授

2017.09-2021.06：北京大学，城市与环境学院，博士 导师 万祎教授

2014.09-2017.06：东北农业大学，生命科学学院，硕士 导师 赵越、魏自民教授

2010.09-2014.06：东北农业大学，生命科学学院，学士

学术兼职：

Chemosphere、Science of the total environment等期刊审稿人

在研项目：

1、国家自然科学基-青年科学基金项目：环境中甲状腺激素受体活性物质的蛋白亲和高通量鉴定及心脏毒性研究，主持

2、中国博士后科学基金面上资助：环境中甲状腺激素干扰物质的高通量鉴定，主持

3、国家自然科学基金面上项目：促甲状腺癌环境污染物的生物指示分子和致毒机制研究，项目骨干

4、北京市自然科学基金杰青项目：持久性有机污染物诱发代谢紊乱的关键分子及毒理机制，参与

5、国家重点研发计划课题：长江、黄河流域健康风险物质鉴定及清单研究，参与

主要论文、成果：

1、Hongyang Cui, Xu Zhang, Yumeng Wang, Xu Zhang, Jie Lv. Binding characteristics of heavy metal contaminations and sewage sludge DOM products: Determination based on complexing-variance partitioning analysis. Chemical Engineering Journal, 2024: 151387.

2、Liming Jia, Qi Yang, Hongyang Cui*. Insight into the dynamics of dissolved organic matter components under latitude change perturbation. Ecotoxicology and Environmental Safety, 2024, 269: 115734.

3、Hongyang Cui, Chunhao Zhang, Caihong Song, Lina Xie, Guogang Zhang, Li Zhao, Yue Zhao, and Zimin Wei. Remediation of Solid Wastes and Stabilization of Heavy Metal Contaminations Using Humid Acid Ligands. ACS Sustainable Resource Management, 2024, 1(3): 471-479.

4、Hongyang Cui, Yue Zhao, Li Zhao, Zimin Wei, Characterization of Mercury Binding to Different Molecular Weight Fractions of Dissolved Organic Matter. Journal of Hazardous Materials, 2022, 431(128593).

5、Hongyang Cui, Xin Wen, Zhanhai Wu, Yue Zhao, Qian Lu, Zimin Wei, Insight into complexation of Cd(II) and Cu(II) to fulvic acid based on feature recognition of PARAFAC combined with 2DCOS, Journal of Hazardous Materials, 2022, Volume 440, 129758.

6、Liu Liu†, Hongyang Cui†, Yixuan Huang, Yulan Zhou, Jianying Hu, Yi Wan. Enzyme-Mediated Reactions of Phenolic Pollutants and Endogenous Metabolites as an Overlooked Metabolic Disruption Pathway. Environmental Science & Technology 2022 56 (6), 3634-3644.

7、Hongyang Cui, Shubo Zhang, Maoyuan Zhao, Yue Zhao, Zimin Wei, Parallel faction analysis combined with two-dimensional correlation spectroscopy reveal the characteristics of mercury composting-derived dissolved organic matter interactions. Journal of Hazardous Materials, 2020, 384(121395).

8、Hongyang Cui, Yue Zhao, Yanni Chen, Xu Zhang, Xueqin Wang, Qian Lu, Liming Jia, Zimin Wei, Assessment of phytotoxicity grade during composting based on EEM/PARAFAC combined with projection pursuit regression, Journal of Hazardous Materials, Volume 2017, 326: 10-17.

9、Hongyang Cui, Hong Chang, Hongjin Zheng, Yi Wan, Determination and occurrence of sulfonamide transformation products in surface waters. Science of the total environment, 2021, 779(146562).

10、Hongyang Cui, Yue Zhao, Li Zhao, Caihong Song, Qian Lu, Zimin Wei, Insight into the Soil Dissolved Organic Matter Ligand–Phenanthrene-Binding Properties Based on Parallel Faction Analysis Combined with Two-Dimensional Correlation Spectroscopy. Journal of Agricultural and Food Chemistry. 2022 70 (43), 13873-13881.

11、Hongyang Cui, Lina Xie, Guogang Zhang, Yue Zhao, and Zimin Wei. Revealing the Inner Changes of Component Composition Derived from DOM PARAFAC Based on Two-Dimensional Correlation Spectroscopy. Molecules 2022, 27, no. 21: 7316.

12、Hongyang Cui, Jianhong Shi, Linlin Qiu, Yue Zhao, Zimin Wei, Xinglei Wang, Liming Jia, Jiming Li. Characterization of chromophoric dissolved organic matter and relationships among PARAFAC components and water quality parameters in Heilongjiang, China. Environmental Science and Pollution Research, 2016, 23(10): 10058-10071.

授权专利情况

1、Yi Wan; Hongyang Cui; Hang Liu; Shixiong Gao; METHOD AND A KIT FOR SIMULATIONEOUS ANALYS IS OF THYROID HORMONES AND RELATED METABOLITES IN SERUM, 2021-8-10, 美国, US 11,085,936 B2 (美国专利)

2、Yi Wan; Hongyang Cui; Application of MIT and/or DIT as thyroid cancer marker and kit，PCT/CN2019/121783 (PCT专利)

3、万祎；崔洪洋 MIT和/或DIT作为甲状腺癌标志物的应用及试剂盒, 2022-01-11, 中国, ZL 20201114 6266.9

4、魏自民；崔洪洋；赵越；贾立明；于会彬；李艳杰 一种测定堆肥过程中腐殖酸类物质演变过程的方法，2020-12-22，中国，CN107290320B

5、万祎；刘航；彭超；崔洪洋；高世雄 一种运动生物的视频追踪方法和装置，2022-07-26，中国，CN108830881B

6、赵越；魏雨泉；魏自民；卢倩；王雪芹；曹振宇；崔洪洋；赵艺；刘海龙 一种基于最大供磷力的堆肥施用方法，2018-10-26，中国，CN105900586B

申请专利情况

1、万祎；杨辉；崔洪洋；张倩男 EGFR蛋白磷酸化的抑制试剂及抑制方法和用途，中国，202310055904.3

2、万祎；孙轶斌；崔洪洋 一种卤代有机物的高灵敏高通量扫描分析方法，中国，2022101289174